is an online resource for the investigation of
AU-rich elements (ARE)
in vertebrate mRNA UTR sequences hosted at the
Institute of Theoretical Chemistry
University of Vienna
. AREs are one of the most prominent cis-acting regulatory elements found in 3' vertebrate, untranslated regions of mRNAs. Various ARE-binding proteins that possess RNA stabilizing or destabilizing functions are recruited by sequence-specific motifs. This online resource allows detailed investigation of these functional elements by analysis of the
these motifs are embedded in. Moreover, AREsite provides information about experimentally validated targets from extensive literature search.
: You can get instant help by clicking the little
symbols. This web page works best in the free Internet Browser
, which has native support for
. If you use any other browser you might need to install the
Adobe SVG plugin
to use the full functionality of this site.
If you have suggestions or ideas to improve this website, please, feel free to contact us at firstname.lastname@example.org.
October 1, 2010
AREsite 1.0 officially released.
November 12, 2010
AREsite manuscript officially published in Nucleic Acids Research.
Search for a specific gene
Enter the identifier of your gene in the field below. You can use
. If your identifier cannot be mapped to an unique entry in our database, you will be forwarded to an intermediate page, where you can select the appropriate entry. Find belwo a list of identifiers you can enter if your are, for example, looking for Interleukin 6:
IL-6, B-cell stimulatory factor 2, BSF-2, Interferon beta-2, Hybridoma growth factor, CTL differentiation factor, CDF
Ensemble gene id:
Ensemble transcript ids:
ENST00000258743, ENST00000401630, ...
mRNA Accession numbers:
X04403, M14584, ...
Select sequence motifs
Select motifs you want to search for from the box below. The core motif
is present in all motifs.
is the IUPAC letter for
. Only strict matches (no mismatch allowed) are reported.
Check all ARE motifs
By default only the transcript with the highest number of AUUUA matches is analyzed (representative transcript). If you want to analyze all transcripts of the corresponding gene, uncheck the box below.
If you have an Internet browser that is not able to render SVG images correctly, you might want to check the option "generate only static images". SVG images are then converted to PNG images, which any browser can display. The interactivability is, however, lost.
do detailed analysis on
generate only static images (if your browser does not understand SVG)
University of Vienna, 2010