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ENSG00000132356: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Homo sapiens)

AMPK alpha-1 chain, EC 2.7.11.1

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Number of protein-coding transcripts corresponding to the submitted sequence identifier: 1
Representative transcript (= transcript with the highest number of ATTTA motifs): ENST00000397128
Total number of distinct positions containing the selected motif ATTTA: 18
Total number of distinct positions containing the selected motif WWWWATTTAWWWW: 1
Total number of distinct positions containing the selected motif WWATTTAWW: 5

Transcript ENST00000397128 (representative transcript)

Length 3' UTR: 3,399 nt
A+T content in 3' UTR: 0.68
RNAplfold output: [ opening energies | probabilities of being unpaired ] (whole transcript)
Download/Linkout:[ download as annotated Genbank file | Linkout to ]
WWATTTAWW: 1.42 fold-enrichment
WWWWATTTAWWWW: 1.33 fold-enrichment
ATTTA: 1.08 fold-enrichment
Site 2046-2054:AAATTTATT (WWATTTAWW)  
Opening energy for the core AUUUA pentamer: 0.54 kcal/mol (short range) / 0.78 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.42 (short range) / 0.28 (mid range)
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Site 2534-2542:TAATTTAAA (WWATTTAWW)  
Opening energy for the core AUUUA pentamer: 0.44 kcal/mol (short range) / 0.66 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.49 (short range) / 0.34 (mid range)
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Site 3197-3205:ATATTTAAA (WWATTTAWW)  
Opening energy for the core AUUUA pentamer: 0.16 kcal/mol (short range) / 1.39 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.77 (short range) / 0.10 (mid range)
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Site 4156-4164:ATATTTAAA (WWATTTAWW)  
Opening energy for the core AUUUA pentamer: 1.17 kcal/mol (short range) / 1.57 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.15 (short range) / 0.08 (mid range)
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Site 4599-4607:TAATTTAAA (WWATTTAWW)  
Opening energy for the core AUUUA pentamer: 0.43 kcal/mol (short range) / 0.77 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.50 (short range) / 0.29 (mid range)
[ Highlight | show accessibility plot | show sequence logo | show alignment ]
Site 4154-4166:AAATATTTAAATA (WWWWATTTAWWWW)  
Opening energy for the core AUUUA pentamer: 1.17 kcal/mol (short range) / 1.57 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.15 (short range) / 0.08 (mid range)
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Site 1834-1838:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.40 kcal/mol (short range) / 1.44 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.52 (short range) / 0.10 (mid range)
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Site 1965-1969:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.82 kcal/mol (short range) / 1.22 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.26 (short range) / 0.14 (mid range)
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Site 1995-1999:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.58 kcal/mol (short range) / 0.92 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.39 (short range) / 0.22 (mid range)
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Site 2048-2052:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.54 kcal/mol (short range) / 0.78 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.42 (short range) / 0.28 (mid range)
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Site 2536-2540:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.44 kcal/mol (short range) / 0.66 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.49 (short range) / 0.34 (mid range)
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Site 2577-2581:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 1.17 kcal/mol (short range) / 2.06 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.15 (short range) / 0.04 (mid range)
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Site 2930-2934:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.89 kcal/mol (short range) / 0.87 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.24 (short range) / 0.25 (mid range)
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Site 3199-3203:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.16 kcal/mol (short range) / 1.39 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.77 (short range) / 0.10 (mid range)
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Site 3423-3427:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.27 kcal/mol (short range) / 1.35 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.64 (short range) / 0.11 (mid range)
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Site 3533-3537:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 1.11 kcal/mol (short range) / 1.03 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.17 (short range) / 0.19 (mid range)
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Site 3854-3858:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.96 kcal/mol (short range) / 1.44 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.21 (short range) / 0.10 (mid range)
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Site 3878-3882:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 1.48 kcal/mol (short range) / 1.76 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.09 (short range) / 0.06 (mid range)
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Site 4158-4162:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 1.17 kcal/mol (short range) / 1.57 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.15 (short range) / 0.08 (mid range)
[ Highlight | show accessibility plot | show sequence logo | show alignment ]
Site 4601-4605:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.43 kcal/mol (short range) / 0.77 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.50 (short range) / 0.29 (mid range)
[ Highlight | show accessibility plot | show sequence logo | show alignment ]
Site 4745-4749:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 1.12 kcal/mol (short range) / 1.83 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.16 (short range) / 0.05 (mid range)
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Site 5013-5017:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 1.09 kcal/mol (short range) / 1.40 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.17 (short range) / 0.10 (mid range)
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Site 5041-5045:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.67 kcal/mol (short range) / 1.21 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.34 (short range) / 0.14 (mid range)
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Site 5074-5078:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.98 kcal/mol (short range) / 0.73 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.20 (short range) / 0.30 (mid range)
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3' UTR sequence

Highlight motifs in 3' UTR sequence: all WWATTTAWW | all WWWWATTTAWWWW | all ATTTA | none

Overview conservation analysis

The tree below summarizes the conservation pattern of the detected ARE motifs. Circles indicate genomic MAF alignments, while boxes are used transcript alignments. Signs in grey indicate that the sequence is present in the alignment, but the correpsonding ARE pattern was not detected.