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ENSG00000162409: 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens)

AMPK alpha-2 chain, EC 2.7.11.1

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Number of protein-coding transcripts corresponding to the submitted sequence identifier: 1
Representative transcript (= transcript with the highest number of ATTTA motifs): ENST00000371244
Total number of distinct positions containing the selected motif ATTTA: 33
Total number of distinct positions containing the selected motif WWATTTAWW: 3

Transcript ENST00000371244 (representative transcript)

Length 3' UTR: 7,622 nt
A+T content in 3' UTR: 0.67
RNAplfold output: [ opening energies | probabilities of being unpaired ] (whole transcript)
Download/Linkout:[ download as annotated Genbank file | Linkout to ]
ATTTA: 0.98 fold-enrichment
WWATTTAWW: 0.44 fold-enrichment
Site 1895-1899:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.52 kcal/mol (short range) / 0.74 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.43 (short range) / 0.30 (mid range)
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Site 2148-2152:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.62 kcal/mol (short range) / 0.75 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.36 (short range) / 0.30 (mid range)
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Site 2201-2205:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.70 kcal/mol (short range) / 0.66 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.32 (short range) / 0.34 (mid range)
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Site 2399-2403:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.66 kcal/mol (short range) / 0.64 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.34 (short range) / 0.35 (mid range)
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Site 2485-2489:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.96 kcal/mol (short range) / 1.19 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.21 (short range) / 0.14 (mid range)
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Site 2535-2539:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.53 kcal/mol (short range) / 0.77 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.42 (short range) / 0.29 (mid range)
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Site 3056-3060:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.75 kcal/mol (short range) / 1.11 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.30 (short range) / 0.16 (mid range)
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Site 3078-3082:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.81 kcal/mol (short range) / 0.96 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.27 (short range) / 0.21 (mid range)
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Site 3093-3097:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.44 kcal/mol (short range) / 0.57 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.49 (short range) / 0.40 (mid range)
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Site 3132-3136:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.55 kcal/mol (short range) / 0.77 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.41 (short range) / 0.29 (mid range)
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Site 3856-3860:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.47 kcal/mol (short range) / 0.98 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.47 (short range) / 0.20 (mid range)
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Site 3883-3887:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.69 kcal/mol (short range) / 0.89 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.33 (short range) / 0.24 (mid range)
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Site 3907-3911:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.68 kcal/mol (short range) / 1.21 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.33 (short range) / 0.14 (mid range)
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Site 5015-5019:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.59 kcal/mol (short range) / 0.60 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.38 (short range) / 0.38 (mid range)
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Site 5357-5361:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 1.21 kcal/mol (short range) / 1.47 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.14 (short range) / 0.09 (mid range)
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Site 5418-5422:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 1.12 kcal/mol (short range) / 1.52 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.16 (short range) / 0.08 (mid range)
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Site 5486-5490:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.90 kcal/mol (short range) / 1.74 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.23 (short range) / 0.06 (mid range)
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Site 5598-5602:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.23 kcal/mol (short range) / 2.24 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.69 (short range) / 0.03 (mid range)
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Site 5602-5606:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.26 kcal/mol (short range) / 1.76 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.66 (short range) / 0.06 (mid range)
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Site 5653-5657:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.14 kcal/mol (short range) / 0.20 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.79 (short range) / 0.72 (mid range)
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Site 5864-5868:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.92 kcal/mol (short range) / 1.84 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.22 (short range) / 0.05 (mid range)
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Site 6439-6443:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 1.59 kcal/mol (short range) / 2.99 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.08 (short range) / 0.01 (mid range)
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Site 7030-7034:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.33 kcal/mol (short range) / 0.41 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.58 (short range) / 0.51 (mid range)
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Site 7130-7134:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.29 kcal/mol (short range) / 0.51 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.63 (short range) / 0.43 (mid range)
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Site 7681-7685:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.47 kcal/mol (short range) / 0.48 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.47 (short range) / 0.46 (mid range)
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Site 7752-7756:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.88 kcal/mol (short range) / 0.96 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.24 (short range) / 0.21 (mid range)
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Site 7781-7785:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.50 kcal/mol (short range) / 0.58 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.45 (short range) / 0.39 (mid range)
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Site 8306-8310:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.37 kcal/mol (short range) / 0.56 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.55 (short range) / 0.40 (mid range)
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Site 8319-8323:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 1.40 kcal/mol (short range) / 1.80 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.10 (short range) / 0.05 (mid range)
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Site 8525-8529:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.63 kcal/mol (short range) / 0.53 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.36 (short range) / 0.42 (mid range)
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Site 8688-8692:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 1.10 kcal/mol (short range) / 1.38 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.17 (short range) / 0.11 (mid range)
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Site 8867-8871:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 0.21 kcal/mol (short range) / 0.37 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.71 (short range) / 0.55 (mid range)
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Site 8978-8982:ATTTA (ATTTA)  
Opening energy for the core AUUUA pentamer: 1.46 kcal/mol (short range) / 1.35 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.09 (short range) / 0.11 (mid range)
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Site 2199-2207:TTATTTAAA (WWATTTAWW)  
Opening energy for the core AUUUA pentamer: 0.70 kcal/mol (short range) / 0.66 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.32 (short range) / 0.34 (mid range)
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Site 5651-5659:TAATTTATT (WWATTTAWW)  
Opening energy for the core AUUUA pentamer: 0.14 kcal/mol (short range) / 0.20 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.79 (short range) / 0.72 (mid range)
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Site 7750-7758:TAATTTAAA (WWATTTAWW)  
Opening energy for the core AUUUA pentamer: 0.88 kcal/mol (short range) / 0.96 kcal/mol (mid range)
Probability of being unpaired for the core AUUUA pentamer: 0.24 (short range) / 0.21 (mid range)
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3' UTR sequence

Highlight motifs in 3' UTR sequence: all ATTTA | all WWATTTAWW | none

Overview conservation analysis

The tree below summarizes the conservation pattern of the detected ARE motifs. Circles indicate genomic MAF alignments, while boxes are used transcript alignments. Signs in grey indicate that the sequence is present in the alignment, but the correpsonding ARE pattern was not detected.